Sheida Amini - Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Behzad Barekatain - Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Majid Mohammadizadeh - Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Silva Hovsepian - Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Background: Nasal Continuous Positive Airway Pressure (N-CPAP) is the standard method of respiratory support in neonatal intensive care units, and this method is used for almost all infants with respiratory distress syndrome (RDS) for respiratory support. The position of infants under N-CPAP (prone and supine) affects the amount of blood supply. This study aimed to compare the prone \\and supine positions, followed by the investigation of their effects on various respiratory parameters and prematurity complications in premature infants with RDS treated with N-CPAP.Methods: This randomized clinical trial was conducted on ۱۲۷ premature infants under N-CPAP treatment in the neonatal intensive care units of Al-Zahra and Shahid Beheshti hospitals, Isfahan, Iran. Babies were placed in two groups of ۶۸ and ۵۹ cases with supine and prone positions, respectively. The duration of N-CPAP, the number of prescribed doses of surfactant, the need for mechanical ventilation, time to full feed, and positive end-expiratory pressure (PEEP) were investigated in this study. The obtained data were then analyzed using SPSS software (version ۲۲).Results: The mean±SD values of gestational age and birth weight of the neonates were ۳۱.۸۸±۱.۳۰ weeks and ۱۶۷۲.۴۰±۴۴۳.۶۷ g, respectively. The frequency of using different modes of mechanical ventilation was significantly lower in the prone position group, compared to the supine position group ([۱۷% vs. ۳۲.۴%], X۲[۳, N=۱۲۷]=۷.۹۵, P<۰.۰۵). There was a significant correlation between position and using mechanical ventilation during the first ۷۲ hours (P=۰.۰۴, Correlation Coefficient=۰.۱۸۲). Multivariate analysis indicated a significant correlation between position and mean time of PEEP (P<۰.۰۰۱, F=۱۳.۶۷), mean of surfactant use (P=۰.۰۱۳, F=۶.۳۸), and time to full feed (P=۰.۰۰۲, F=۱۰.۲۹).Conclusion: The results of this study showed that placing preterm infants with RDS who are treated with N-CPAP in the prone position reduces complications related to being preterm or using N-CPAP.

N-CPAP, Prone position, Preterm newborn, RDS, Supine Position