Design andsynthesisof novel sulfonamides and their antibacterialactivitiesevaluation
عنوان مقاله: Design andsynthesisof novel sulfonamides and their antibacterialactivitiesevaluation
شناسه ملی مقاله: COSPC01_014
منتشر شده در کنفرانس ملی سنتز آلی و شیمی دارویی در سال 1392
شناسه ملی مقاله: COSPC01_014
منتشر شده در کنفرانس ملی سنتز آلی و شیمی دارویی در سال 1392
مشخصات نویسندگان مقاله:
Ahmad Reza Massah - Department of Chemistry, Shahreza Branch, Islamic Azad University, ۸۶۱۴۵–۳۱۱,Shahreza, Iran
Tooba Khazaeli - Department of Chemistry, Shahreza Branch, Islamic Azad University, ۸۶۱۴۵–۳۱۱,Shahreza, Iran
خلاصه مقاله:
Ahmad Reza Massah - Department of Chemistry, Shahreza Branch, Islamic Azad University, ۸۶۱۴۵–۳۱۱,Shahreza, Iran
Tooba Khazaeli - Department of Chemistry, Shahreza Branch, Islamic Azad University, ۸۶۱۴۵–۳۱۱,Shahreza, Iran
This Letter describes the design and synthesis of novel sulfonamides derived from p-anisidine in excellent yields inthe absence of organic bases. These sulfonamides have been prepared by the condensation of ۵-acetylamino-۲-methoxy benzenesulfonyl chloride with different amines and then amid werehydrolyzed to amino group.Thestructure of the synthesized compounds has been confirmed by IR, ۱H NMR and ۱۳C NMR data.All the compoundswere screened in vitro for their antibacterial activities. Preliminary results indicated that ۵-Amino-N-(۲-hydroxyphenyl)-۲-methoxy-benzenesulfonamide, to be the most potent compounds against all the tested strains.
کلمات کلیدی: p-anisidine,sulfonamide, amine, chlorosulfonic acid,solvent-free
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1764568/