Nesa Haghgoo - Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box ۴۱۳۳۵-۱۹۱۴, Rasht, Iran
Manouchehr Mamaghani - Department of Chemistry, Faculty of Sciences, University of Guilan, P. O. Box: ۴۱۳۳۵-۱۹۱۴, Rasht, Iran
Elham Saberikhah - Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box ۴۱۳۳۵-۱۹۱۴, Rasht, Iran
Roghayeh Hossein Nia - Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box ۴۱۳۳۵-۱۹۱۴, Rasht, Iran

A novel and practical method for the synthesis of pyridopyrimidine-indole hybrids, using a three-component reaction of thiouracil or ۶-amino-N,N-dimethyluracil, various aryl aldehydes and ۳-cyanoacetyl indole in the presence of a green heterogeneous nano-catalyst γ-Fe۲O۳@HAp@PBABMD@Cu was developed. This protocol furnished the desired products in high yields (۸۲-۹۵%) and lower reaction times (۱۸-۴۰ min).

Pyridopyrimidine, ۳-Cyanoacetylindole, ۶-Amino-N, N-dimethyluracil, Aanocatalyst, γ-Fe۲O۳@HAp@PBABMD@Cu