Mohammad Anary-Abbasinejad - Department of chemistry, Vali-e-Asr University, Rafsanjan, ۷۷۱۷۶, Iran
Maryam Jaafari - Department of Chemistry, Vali-e-Asr University,Rafsanjan ۷۷۱۷۶, Iran
Mahdiyeh Talebizadeh - Department of Chemistry, Vali-e-Asr University,Rafsanjan ۷۷۱۷۶, Iran

A facile synthesis of highly functionalized ۲H-iminopyran derivatives by the multi-component reaction of cyclohexyl isocyanide, dialkyl acetylenedicarboxylates, arylglyoxals and arylamines is described. The zwitterionic intermediate produced by addition of cyclohexyl isocyanide to electron-deficient acetylene diesters was trapped by the electrophilic imine moiety of α-iminoketones, derived from arylglyoxals and arylamines, to afford an inner salt intermediate which converted to ۲H-iminopyran derivatives by an intramolecular cyclization.

α-Iminoketones, Isocyanide, Iminopyrans, Four-component reaction, Arylglyoxals