Bi Bi Fatemeh Mirjalili - Yazd University
Sara Azad - chemistry department , yazd university
Abdolhamid Bamoniri - Departent of Organic Chemistry, Faculty of Chemistry, University of Kashan

TiCl۴/nano-cellulose as a biodegradable and eco-friendly Lewis acid catalyst was synthesized via reaction of nano-cellulose and TiCl۴. This catalyst was characterized and used for synthesis of asymmetric highly functionalized tetrahydropyridines via a five-component condensation reaction of p-substituted anilines, aldehydes and ethyl acetoacetate under solvent-free condition. Simple methodology, eco-friendly catalyst, clean procedure, easy work-up and high yields are some of the important advantages of this protocol.

Nano-TiCl۲/cellulose, Tetrahydropyridines, Nano-cellulose, Lewis acid catalyst, biodegradable catalyst