M Maghsoodlu, - Sistan & Baluchestan University, Zahedan, IRAN
Farzaneh Mohamadpour - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box ۹۸۱۳۵-۶۷۴ Zahedan, Iran
Mojtaba Lashkari - Faculty of Science, Velayat University, Iranshar, Iran
Nourallah Hazeri - Chemistry department of, The University of Sistan and Baluchestan, P. O. Box ۹۸۱۳۵-۶۷۴, Zahedan, Iran

Convenient procedure for the synthesis of corresponding pyrano[۲,۳-d]pyrimidine derivatives were developed via one-pot three-component reaction of aryl aldehyde derivatives, malononitrile with barbituric acids in the presence of copper (II) chloride dihydrate (CuCl۲.۲H۲O) as highly efficient Lewis acid catalyst. This protocol has advantages such as readily and inexpensive catalyst, high reaction yields, eco-friendly solvent and high atom-economy.

Sustainable procedure, Copper(II) chloride dihydrate (CuCl۲.۲H۲O), Water/ethanol media, Pyrano[۲, ۳-d]pyrimidine derivatives, One-pot reaction