Hamid Beyzaei - Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
Hossein Heidari - Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
Reza Aryan - Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran

Novel N-amino benzylthiolates were synthesized via multicomponent reaction of malononitrile, isothiocyanates and benzyl halides under conventional and solvent-free conditions. Various electron-donating and -withdrawing substitutes within both isothiocyanates and benzyl halides were used to demonstrate the efficiency of new methodology. A broad spectrum of antibacterial and antifungal activities were observed especially within benzyl halides containing electron-withdrawing aryl substituents.

Multicomponent synthesis, Solvent-free condition, N-Amino benzylthiolate, Antibacterial Activity, Antifungal property