Khodabakhsh Niknam - Persian Gulf University
Alireza Hosseini - Persian Gulf University

Silica-bonded N-propyldiethylenetriamine (۷) is employed as a recyclable heterogeneous solid base catalyst for the synthesis of ۲-amino-۳,۵-dicarbonitrile-۶-thiopyridines through pseudo four-component condensation reaction between aromatic aldehydes, malononitrile, and ۲-amino-thiophenol in refluxing ethanol. Silica-bonded N-propyldiethylenetriamine showed much the same efficiency when used in consecutive reaction runs.

۲-Amino-۳, ۵-dicarbonitrile-۶-thiopyridines, Heterogeneous catalysts, Solid bases, Synthesis, Multi-component reactions