Eveline Vandenwinckel - Autonoma University of Madrid
Andres de la Escosura - Autonoma University of Madrid
Tomas Torres - Autonoma University of Madrid

In this article, we describe a photosensitizer (PS) whose ability to generate singlet oxygen (۱O۲) and fluorescence emission has been designed as tumor responsive. More specifically, the PS consists of a silicon phthalocyanine (SiPc) core, axially substituted with two subphthalocyanine (SubPc) units, covalently linked by a disulfide linker, which is cleavable in the presence of a strong reducing agent. Initially, the SubPc units quench the SiPc fluorescent and ۱O۲-generating properties, most probably by electronic energy transfer. Upon entering a reducing environment, e.g., like those in tumor cells, the disulfide linker would be cleaved and the quenching would be undone, resulting in a sudden generation of ۱O۲ and a strong fluorescence of both the SiPc and SubPc units. Herein, this behavior has been probed in solution by means of using DTT as the reducing agent that induces the PS activation.

Phthalocyanine, Subphthalocyanine, Triad, Photosensitizer, Theranostics