Synthesis of Bis-۴-hydroxycoumarins via a Multi Component Reaction Using Silica Boron-sulfuric Acid Nanoparticles (SBSANs) as an Efficient Heterogeneous Solid Acid Catalyst
عنوان مقاله: Synthesis of Bis-۴-hydroxycoumarins via a Multi Component Reaction Using Silica Boron-sulfuric Acid Nanoparticles (SBSANs) as an Efficient Heterogeneous Solid Acid Catalyst
شناسه ملی مقاله: JR_ORGC-2-2_007
منتشر شده در در سال 1395
شناسه ملی مقاله: JR_ORGC-2-2_007
منتشر شده در در سال 1395
مشخصات نویسندگان مقاله:
Habib Ollah Foroughi - Department of scince, Islamic AZad University, Fasa branch
Ali Khalafi-Nezhad - Department of Chemistry, Shiraz University, Shiraz,۷۱۴۵۴, I.R.Iran
خلاصه مقاله:
Habib Ollah Foroughi - Department of scince, Islamic AZad University, Fasa branch
Ali Khalafi-Nezhad - Department of Chemistry, Shiraz University, Shiraz,۷۱۴۵۴, I.R.Iran
The silica boron sulfuric acid nanoparticles (SBSANs) as an efficient heterogeneous solid acid catalyst with both Brønsted and Lewis acidic sites catalyzed the preparation of bis-۴-hydroxycoumarin derivatives using reaction of aldehydes and ۴-hydroxycoumarin under mild and solvent-free condition at room temperature. This new and efficient methodology has advantages in comparison with currently used methods such as: easy work-up, simple separation of catalyst from the reaction mixture, reusability and lower catalyst loading, relatively short reaction time, eco-friendly with environment, excellent yields, simple purification of products and mild reaction condition. Using this method a range of biologically active bis-۴-hydroxycoumarin derivatives were synthesized in good to excellent yield. The catalyst system was reusable at least for ۵ times in this reaction without significant decreasing in its catalytic activity.
کلمات کلیدی: Silica boron-sulfuric acid nanoparticles (SBSANs), Solid acid, Lewis-protic acid, Biscoumarin
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1766312/