Mehrnoosh Kangani - Department of Chemistry, University of Sistan and Baluchestan, P.O. Box ۹۸۱۳۵ – ۶۷۴, Zahedan, Iran
Nourallah Hazeri - Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan ۹۸۱۳۵-۶۷۴, Iran
Malek Taher Maghsoodlou - Department of Chemistry, University of Sistan and Baluchestan, P.O. Box ۹۸۱۳۵ – ۶۷۴, Zahedan, Iran
Ali Ebrahimi - Department of Chemistry, University of Sistan and Baluchestan, P.O. Box ۹۸۱۳۵ – ۶۷۴, Zahedan, Iran

Cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of ۶-amino-۴-aryl-۳-methyl-۱,۴-dihydropyrano[۲,۳-c]pyrazole-۵-carbonitrile derivatives using hydrazine monohydrate, ethyl acetoacetate, malononitrile and aryl aldehydes, under solvent-free and thermal conditions. The use of non-toxic and inexpensive catalyst, short reaction time, clean work-up and good yields of the products are advantages of this method.

Cellulose, Reusable catalyst, ۱, ۴-Dihydropyrano[۲, ۳-c]pyrazole, Solvent-free condition, Aryl aldehyde, Hydrazine monohydrate