زهرا صفایی - Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
سعید قربانی - Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
زهرا صلواتیها - Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
احمد توکلی - Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
سیدجلال کیانی - Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
سیدحمیدرضا منوری - Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Background and Aims: Human herpes virus types ۶ and ۷ (HHV-۶, HHV-۷) can remain latent in the urogenital tract epithelial cells. Varicella-Zoster virus (VZV) is among the Alphaherpesviruses infecting most people during childhood. This virus can remain latent in the ganglionic neurons. The latent infection can reactivate through weakness, suppression of the immune system, and aging. Therefore, this study investigated the molecular prevalence of HHV-۶, HHV-۷, and Varicella-Zoster virus in sperm samples from infertile men. Materials and Methods: Sperm samples from ۸۲ infertile patients were collected from infertility centers in Tehran. Chromatin health levels and sperm DNA examinations were carried out using sperm DNA fragmentation index kits. Viral nucleic acids were extracted from the samples. The presence of VZV, HHV-۶, and HHV-۷ genomes was examined through the conventional polymerase chain reaction assay. Results: The average age was ۳۷.۳ ± ۶.۱ years. The mean sperm motility percentage was ۳۳.۶ ± ۲%. Infertile men's mean DNA fragmentation index was ۲۷.۲ ± ۱.۲. This study shows a ۷.۳% and ۴.۹% prevalence for HHV-۶ and VZV, respectively, and the absence of HHV-۷ in sperm specimens. Conclusion: Although the infection rates of these herpesviruses seem relatively low, more comprehensive and multi-center studies are required to obtain more accurate results.

Herpesviridae, HHV, Infertility, Sexually transmitted infections, VZV, HHV-۶, HHV-۷, VZV, اسپرم, ناباروری, مردان