Masoumeh Heidaritajan - Department of Medical Science, Faculty of Medicine, University of Georgia, Tbilisi, Georgia
Maryam Jafarian Anvar - Department of Medical Science, Faculty of Medicine, University of Georgia, Tbilisi, Georgia
Seyed Amirali Ghasemi - Student research Commitee , School of Dentistry , Guilan university of Medical Sciences , Rasht , Iran

Aspirin has become one of the most frequently used and cheapest drugs in medicine till now. Since its first synthesis in ۱۸۹۷, several medicinal roles and mechanisms of action of Aspirin have become apparent. Since its emergence, the COVID-۱۹ pandemic has been ravaging the medical and economic sectors even with the significant vaccination advances. In severe presentations, the disease of SARS-CoV-۲ can manifest with life-threatening thromboembolic and multi-organ repercussions provoking notable morbidity and mortality. Aspirin, due to its well-known properties and multiple molecular targets, and ought to its extensive clinical use, has been perceived as a potential therapeutic agent for COVID-۱۹. Aspirin acts at multiple cellular targets to achieve its anti-inflammatory and anti-platelet effects. Although initial promising clinical data describing aspirin role in COVID-۱۹ has appeared, evidence supporting its use remains fragile and premature. In this article, we highlight the history of Aspirin, a novel mechanism of action, and its uses. Also included is a brief statement of emerging new applications and principal mechanisms by which Aspirin inhibits acute inflammation and alters platelet-biology; therefore, hypothesized that Aspirin might prove highly beneficial as a novel therapeutic drug for combating severe acute inflammation and thrombosis associated with the cytokine storm in COVID -۱۹ patients.

Aspirin, mechanism of action, Uses, COVID-۱۹