Melika Zanganeh Motlagh - School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Nikoo Hossein-Khannazer - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nazanin Mahdavi - Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Pouyan Aminishakib - Department of Pathology, Cancer Institute Hospital, IKHC, Tehran University of Medical Sciences, Tehran, Iran
Massoud Vosough - Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Dental pulp stem cells(DPSCs) are a class of stem cells which originate from dental pulp tissue and possess multiple stem cell characteristics including high clonogenicity, differentiation capacity and immunomodulatory effects.  DPSCs can be used in different stem cell-based therapy to treat a variety of diseases, such as autoimmune, orthopedic, and neurological diseases. Recent studies showed that DPSCs combined with biomaterials provides an effective approach to craniofacial bone regeneration and reconstruction of bone defects. Scaffolds improve cell attachment, proliferation, differentiation, and migration. In the present study we discuss different combination of biomaterials with DPSCs.

Dental pulp stem cells, dentistry, applications, osseointegration, tissue engineering, regeneration