Sara Saedi - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Amirhossein Tayebi - Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Maedeh Ghorbani Kahrizsangi - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Fatemeh Jalalinezhad - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Aryan Ayati - Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Alireza Hadizadeh - Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Bita Badehnoosh - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Atousa Karimi - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

Background: Endometrial scratch (ES) has been suggested to improve assisted reproductive techniques success rates by investigating implantation failure. Objective: In this study, we evaluated the effect of ES on the outcomes of frozen embryo transfer (FET) in women with at least ۲ failed embryo transfer cycles. Materials and Methods: In this historical cohort study, medical data of ۲۳۶ infertile women who underwent in-vitro fertilization-FET at Ebne-sina Infertility Center, Tehran, Iran, from January ۲۰۱۵-December ۲۰۲۱ was extracted from their medical records. Based on having ES before FET, they were assigned to either the scratch (n = ۱۱۸) or the no-scratch group (n = ۱۱۸). We compared these groups regarding pregnancy rates and outcomes. Results: The demographic characteristics were similar in both groups regarding weight, body mass index, the number of previous embryo transfers, and the duration of infertility. However, the scratch group had a slightly higher mean age (۳۲.۳۱ vs. ۲۹.۹۶ yr, p < ۰.۰۰۱). No statistically significant difference was observed between groups regarding pregnancy rate (p = ۰.۸۹). No significant association was observed between scratch, infertility duration, the number of previous FET attempts, and the likelihood of pregnancy in a logistic regression model. No major complications were observed. Conclusion: Hysteroscopic endometrial scratching with scissors probably has no effect on FET outcomes, including pregnancy or live birth rates.

Hysteroscopy, Infertility, Pregnancy rate, Live birth., کلمات کلیدی: هیستروسکوپی, ناباروری, میزان بارداری, تولد زنده.