Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD)
عنوان مقاله: Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD)
شناسه ملی مقاله: JR_AJP-13-6_004
منتشر شده در در سال 1402
شناسه ملی مقاله: JR_AJP-13-6_004
منتشر شده در در سال 1402
مشخصات نویسندگان مقاله:
Ali Beheshti Namdar - Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mitra Ahadi - Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Mousalreza Hoseini - Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hassan Vosoghinia - Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hosein Rajablou - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Salman Farsi - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Amirsadra Zangouei - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hamid Reza Rahimi - Department of Medical Genetics & Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
خلاصه مقاله:
Ali Beheshti Namdar - Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mitra Ahadi - Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Mousalreza Hoseini - Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hassan Vosoghinia - Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hosein Rajablou - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Salman Farsi - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Amirsadra Zangouei - Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hamid Reza Rahimi - Department of Medical Genetics & Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Objective: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes with no consumption of alcohol. Recently, curcumin is a natural polyphenol found in turmeric has been examined for the treatment of NAFLD. This study aimed to assess the efficacy of ۱۶۰ mg/day nano-micelle curcumin on the amelioration of NAFLD by measuring liver enzymes.Materials and Methods: Patients with NAFLD were randomly divided into curcumin (intervention group n=۳۳) and placebo (n=۳۳) groups and at the end of the study, the data of ۵۶ participants who completed the ۲-month intervention were analyzed. Laboratory tests and questionnaires were used to gather information. Both groups received recommendations for lifestyle modification, and were advised to other necessary advices. Patients in the curcumin group received ۱۶۰ mg/day of nano-micelle curcumin in two divided doses for ۶۰ days. The ۲ groups were followed up for two months and clinical and laboratory indices were compared.Results: Our data showed a significant decrease in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the curcumin group (p<۰.۰۱) as well as a significant difference between the groups before and after the intervention in curcumin group (p<۰.۰۵). Interestingly, a meaningful decrease in AST serum level was observed in the intervention group (p<۰.۰۱). Conclusion: Our study demonstrated that short-term supplementation with nano-micelle curcumin results in the reduction of AST and ALT and is beneficial for the treatment of NAFLD.
کلمات کلیدی: Non-alcoholic fatty liver disease, Curcumin, Nano-micelle, Hepatic enzymes
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1804899/