Morteza Talebi Deloee
Bahram Zarmehri
Elham Pishbin
Mona Najaf Najafi
Maryam Salehi

Objectives: Pain management is an important issue in traumatic patients. The aim of this randomized clinical trial was to compare the analgesic effect of intravenous acetaminophen with intravenous morphine sulfate in patients with traumatic diaphyseal long bone fracture. Methods: This double-blind randomized clinical trial was carried out in an academic trauma center in Mashhad, Iran, from February to October ۲۰۱۳. After primary modalities like limb elevation, ice and limb splinting, patients were allocated to receive either acetaminophen ۱۵ mg/kg or morphine sulfate ۰.۱ mg/kg randomly. The pain severity was measured using a visual analogue scale before drug administration and ۵ and ۳۰ minutes after drug administration. Then, the results were compared. Results: Of the ۵۰ patients recruited over ۹ months ۲۶ patients received intravenous morphine sulfate and ۲۴ patients received intravenous acetaminophen. A significant difference was observed between the two groups at ۵ minutes after drug administration; the morphine sulfate group showed more reduction in pain severity after ۵ minutes (P < ۰.۰۰۰۱). However, there was no significant difference in pain severity at ۳۰ minutes after drug administration between the two groups (P = ۰.۸۵). Conclusions: It seems that after ۳۰ minutes, intravenous acetaminophen is as effective as intravenous morphine sulfate in pain management of isolated diaphyseal long bone fracture. However, it should be noted that the analgesic effect of acetaminophen begins with a delay. Thus, we suggest using intravenous acetaminophen when morphine administration is contraindicated.

Intravenous acetaminophen, Intravenous Morphine Sulfate, visual analogue scale, Long bone fracture