Hossain Azizian - Msc of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
Mohammad Ebrahim Rezvani - Assistant professor of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
Mansour Esmaeilidehaj - Assistant professor of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
Seyyed Majid Bagheri - Msc of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran

Objective: Control of weight gain is an important strategy in reducing the diabetes incidence. Recently, herbal drugs have been used as a complementary and alternative medicinal care. This study was conducted to determine the effect of Ferula asafoetida on weight gain, fat accumulation, liver steatosis and leptin level. Materials and Methods: All rats of control and treatment groups received daily tap water (P.O) as vehicle mixed with fructose ۱۰%. Two treatment groups received FAF oleo-gum resin at doses of ۲۵ or ۵۰ mg/kg (P.O). Normal rats received only tap water and standard chow food. Body weights, abdominal fat, size of epididymal adipocyte and serum leptin were recorded. Result: Administration of Ferula asafoetida significantly decreased body weights, abdominal fat and size of epididymal adipocyte compared to untreated rats (P<۰.۰۵). Levels of serum leptin were significantly decreased in treated rats (P<۰.۰۵). Conclusion: This study showed that Ferula asafoetida extract has anti-obesity, fat lowering effects and can prevent liver steatosis in type ۲ diabetic rats. Reduction of serum leptin is associated with protective effects of Ferula asafoetida in obese diabetic rats.

Ferula asafoetida, Diabetes mellitus, Obesity, Adipocyte, Liver, Rat,