Sara Vossoughian - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Seyedeh Tahereh Faezi - Rheumatology Research Center, Tehran University of Medical Sciences
Farhad Shahram - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Hoda Kavosi - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mostafa Qorbani - Non-communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Mohammad Nejadhosseinian - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Hoda Haerian - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Yasaman Ahmadzadeh - Department of Medicine, Roger Williams Medical Center, Providence, Rhode Island, United States.
Mohammad Ali Mozaffari - Department of Medicine, Beaumont Hospital, Dearborn, Michigan, United States.
Fereydoun Davatchi - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Behçet’s disease (BD) is a chronic multisystem disorder with the principal pathological finding of vasculitis, which may involve vessels of different sizes. The concurrence of small and large vessel involvement in BD patients is undetermined. The current study aims to evaluate small vessel involvement in BD patients with large vessel involvement. The study population comprised ۳۵ BD patients with large vessel involvement (cases) and ۳۵ BD patients without large vessel involvement (controls). Small vessel involvement was evaluated in all patients by capillaroscopy. Capillaroscopic findings were compared between the two groups. According to the capillaroscopic findings, all of our BD patients had small vessel involvement. The most prevalent abnormality was tortuosity (۸۷.۱%), followed by enlarged loops (۵۸.۶%) and avascular areas (۵۱.۴%). Capillaroscopy findings between the case and the control groups were not statistically different. There was a significant association between microbleeding and history of erythema nodosum (P-value = ۰.۰۱۵), tortuosity and a history of skin aphthosis (P-value = ۰.۰۱۵), architectural derangement and history of uveitis (P-Value = ۰.۰۲۹), the number of avascular areas and active oral aphthosis (P-value = ۰.۰۲۱), and architectural derangement and increased ESR (P-value = ۰.۰۱۱). There was no difference in nail fold folder involvement between BD patients with and without large vessel involvement; however, some capillaroscopic features were associated with some disease manifestations.

Behçet’s disease, Vascular involvement, Nail fold capillaroscopy, vasculitis