Anahita Nosrati - Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran
Farshad Naghshvar - Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran
Zhila Torabizadeh - Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran
Mohammadreza Haghshenas - Department of Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Hadi Sangsefidi - Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran

Background: Colorectal cancer is one of the most common malignancies worldwide with more than one million new cases. According to the Ministry of Health and Medical Education of Iran, colorectal cancer is the third most common cancer in Iran. Many risk factors are known causes of this disease. However, the molecular mechanisms associated with colorectal cancer are still under investigation. Recent studies have shown that some viruses, particularly human papilloma virus, may be associated with the pathology of colorectal cancer.Methods: This case-control study examined ۹۵ colorectal cancer and ۹۵ normal colon tissue paraffin blocks (control) to identify the relationship between human papilloma virus and colorectal cancer by polymerase chain reaction.Results: Clinicopathological data that included sex, age, tumor grade, stage and location were recorded. All tumor and control groups (totally: ۱۹۰ samples) were negative in terms of the human papilloma virus genome. No relationship between clinico- pathological data and human papilloma virus genome was identified.Conclusions: Regardless of other risk factors for colorectal cancer, a number of studies in different parts of the world have shown that human papilloma virus may be an important factor in the increasing incidence of colorectal cancer. However, we have found no association between human papilloma virus and colorectal cancer in this study.