A Rare Presentation of Acute Myelogenous Leukemia: A Case Report of Vaginal and Uterine Myeloid Sarcoma from Iran

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-10-3_012

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Myeloid or granulocytic sarcoma is an extramedullary tumor of immature granulocytic cells. This condition is rare and has a challenging diagnosis, relying on a high index of suspicion as well as radiology, histology, immunophenotyping, and molecular analyses. We herein report a case of a ۲۵-year-old woman presented with vaginal bleeding and a large pelvic mass involving the vaginal and uterus. A biopsy and immunohistochemical examination of the mass revealed granulocytic sarcoma, and a subsequent bone marrow biopsy confirmed the diagnosis of acute myelogenous leukemia. The patient was treated based on the standard chemotherapy followed by allogeneic bone marrow transplantation from her full-matched sibling donor. After a ۹-months follow-up, there was no notable complication, and the patient is now completely disease-free. Granulocytic sarcoma of the cervix is rare, and awareness of this entity is required for timely diagnosis and effective treatment.

Authors

Sina Salari

Department of Medical Oncology- Hematology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Ali Darakhshandeh

Department of Medical Oncology- Hematology, Isfahan University of Medical Sciences, Isfahan, Iran

Roohollah Gholampour Shahaboddini

Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Azadeh Moghaddas

Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran