Mohammad Javad Yazdanpanah - Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Noorieh Sharifi Sistani - Department of Pathology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Elnaz Hosseini - Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Elham Vosoughi - Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Saeid Hosseini - Department of Otorhinolaryngology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Khajedaluee - Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
Saeid Amel Jamehdar - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Background: The relationship between HPV infection and skin squamous cell carcinoma (SCC) development in immunocompetent individuals is unclear. Therefore, the purpose of this study was to assess the association between HPV infection and skin SCC. Methods: HPV DNA prevalence was evaluated in the paraffin embedded specimens of ۷۰ immunocompetent patients, of which ۳۵ patients had skin SCC and ۳۵ had normal skin. PCR technique and GP۶/۵ primers were utilized for HPV DNA detection. Result: Based on this study, ۱۴.۳% of the cases (۵ of ۳۵, ۲ with low risk and ۳ with high risk viruses) and ۲.۹% of the controls (۱ of ۳۵ with low risk virus) had papilloma viruses. However, there was no significant statistical relationship between the HPV DNA presence and the SCC development in skin. Conclusion: The direct effect of HPV on skin cancerogenesis remains questionable.

Human papilloma virus, Non-melanoma skin cancers, Squamous cell carcinoma