Survival, Recurrence, and Clinicopathological Characteristics in Multifocal and/or Multicentric versus Unifocal Locoregional Breast Cancers: Results of a Large Breast Cancer Registry

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-14-1_012

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Background: Much is still unknown regarding the clinicopathology and prognosis of patients with multifocal/multicentric breast cancer (MMBC). We herein compared the clinicopathology and prognosis of patients with unifocal and MMBCs.Method: This cross-sectional research is a part of Shiraz Breast Cancer Registry (SBCR). We studied all the patients in the SBCR (n=۶۱۴۵). Ultrasound reports were used to differentiate between MMBCs and unifocal breast cancers (BCs). All the patients were examined with mammography and the diagnosis was confirmed postoperatively via pathology reports.Results: After exclusion, ۴۰۴۵ patients entered the study (n=۱۰۷۲ and n=۲۹۷۳ for multifocal/multicentric and unifocal BCs, respectively). The mean follow-up period was ۵۷.۹ (۰.۲۷-۲۷۵) months. Patients with MMBCs had higher rates of mastectomy (۴۸% vs. ۴۰.۱%; P < ۰.۰۰۱) and higher rates of HER-۲ overexpression (۳۲.۱% vs. ۲۶%; P = ۰.۰۰۱) compared with those with unifocal BCs. Tumor size, lymph node involvement, type of axillary management, chemotherapy, radiotherapy, hormonal therapy, recurrence rates, histological grade, lymphovascular invasion, axillary node involvement, estrogen and progesterone receptor expression status, tumor, node, and metastasis staging were not significantly different between the groups. Five-year overall survival was ۸۸.۳% and ۸۹% (P = ۰.۸) for unifocal and MMBCs, respectively; moreover, five-year disease-free survival was ۸۰.۲% and ۸۱.۲% (P = ۰.۴۱), respectively.Conclusion: Despite the controversy regarding prognosis and surgical management in MMBCs, we found that MMBCs had similar clinicopathological features and prognosis compared to unifocal BCs. Survival, recurrence, and metastasis were similar among the two groups.

Authors

Mojtaba Omidvar

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Sedigheh Tahmasebi

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Majid Akrami

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Payam Arasteh

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Vahid Zangouri

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Akbar Safaei

Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Sara Hosseini

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Aida Salehi Nobandegani

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Seyed Morteza Hosseini

Non-communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran

Abdolrasoul Talei

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

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