Shapour Omidvari - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra Eskandari - Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Hamid Nasrollahi - Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Niloofar Ahmadloo - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mansour Ansari - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Seyed Hassan Hamedi - Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Nezhat Khanjani - Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Behnam Kadkhodaei - Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Ahmad Mosalaei - Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Mohammadianpanah - Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Background: Breast cancer is among the most prevalent cancers in women. Radiotherapy is an important part in treatment of breast cancer, associated with some side-effects, including skin dermatitis. Dermatitis may be severe and impair quality of life. Multiple agents have been studied, but no standard treatment is yet available. Silicone based gel (StrataXRT) was promising in some studies in reducing skin inflammation and also radiotherapy-induced dermatitis.Method: This was a randomized trial on ۱۰۰ women with breast cancer who had undergone quadrantectomy for breast cancer. They received StrataXRT gel or best supportive care during radiotherapy. Dermatitis area and grade of dermatitis were measured.Results: Regarding the mean size of radiation-induced dermatitis area, there was a significant difference between the intervention (۳۶.۸۸ cm۲ ± ۶۹.۹۳) and control (۸۳.۸۳ cm۲ ± ۷۹.۳۴) groups (P = ۰.۰۰۲). During radiotherapy, except in the fourth week, dermatitis was significantly more severe in the control group.Conclusion: It seems that StrataXRT is helpful in decreasing radiotherapy-induced dermatitis.

Breast neoplasms, Radiotherapy, Dermatitis