Relationship between Clinicopathologic Features and Recurrence in Ovarian Germ Cell Tumor

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-12-3_010

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Background: We conducted the present study to analyze the clinicopathologic features of patients with malignant ovarian germ cell tumor (MOGCT) with recurrence after ۲ and ۵ years. Method: In this retrospective and analytical-descriptive study, the obtained data included: age, tumor size, histopathological type, tumor stage, lymph node involvement, laterality of tumor, tumor necrosis, and mitosis. We also evaluated the Cox Regression analysis between these variables with recurrence after ۲ and ۵ years. Results: According to our exclusion criteria, we eliminated ۸۱ cases. These cases consisted of the subjects with dysgerminoma (۴۸.۱%), immature teratoma (۲۲.۲%), yolk sac (۱۶%), mix germ cell (۱۱.۱%), non-gestational choriocarcinoma (۱.۲%), and embryonal carcinoma (۱.۲%). We did not observe pure polyembryoma or polyembryoma in combination with mixed germ cell. All the patients received the treatment. The patients’ mean age was ۲۳.۳±۸.۴ years. MOGCT reoccurred in ۱۰ patients after ۲ years and in ۱۳ patients after ۵ years (۱۰ cases in the first ۲ years, and ۳ new cases in the next ۳ years). Most of the cases (۶۴.۲%) were diagnosed to be at stage ۱. The Cox regression analysis between positive lymph node and the recurrence of MOGCT after ۲ years and between stage IV of disease and the recurrence after ۲ years were significant. The Cox regression analysis between laterality, mitosis and necrosis in pathologic slides of the recurrence after ۲ and ۵ years was not significant. Conclusion: Stages and involvement of lymph nodes are two major factors concerning the recurrence of MOGCT. Most recurrences occur in the first ۲ years. Pathologic features (mitosis and necrosis) of MOGCt in the time of diagnosis not correlated with the recurrence of the disease.

Keywords:

Clinicopathologic , Ovarian germ cell tumor , Recurrence , Prognosis

Authors

Mozhdeh Momtahan

Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran

Mojgan Akbarzadeh-Jahromi

Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Saeid Jokar

Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

Shaghayegh Moradi-Alamdarloo

Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran

Fatemeh Sari Aslani

Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Maryam Rohani

Department of Obstetrics and Gynecology, Yasuj University of Medical Sciences, Yasuj, Iran