Clinicopathological Behavior of Mucinous Breast Carcinoma in South of Iran: The Shiraz Breast Cancer Registry

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-12-1_010

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Background: Mucinous breast carcinoma (MBC) is a subtype of breast cancer categorized by the presence of extracellular mucin and has more favorable prognosis than invasive carcinoma of no special type of breast cancer. The present study incorporates ۲۷ years of practical experience from a breast disease research center-based series of cases regarding MBC and invasive ductal carcinoma (IDC).Method: In this retrospective study, we studied the medical documents of ۷,۷۳۹ patients in the Breast Disease Research Center, Shiraz University of Medical Sciences, from December ۱۹۹۳ to January ۲۰۱۹. TNM data, demographic status, pathologic stage, histological grade, hormonal receptor data, recurrence, overall survival (OS), and disease-free survival (DFS) were reviewed. We also statistically evaluated the clinical and histopathological differences of pure, mixed MBC, and IDC using SPSS, version ۲۱.۰ (IBM, USA). P<۰.۰۵ was considered as statistically significant.Results: A total of ۷۸ and ۳۱ patients were observed to have pure and mixed MBC, respectively, and ۵,۷۷۴ breast cancer patients had IDC. The pure MBC group showed a lower histological grade and pathologic stage and a larger tumor size compared with mixed MBC (P<۰.۰۰۱). The pure MBC patients had significantly less perinural and lymphovascular invasion and had less HER-۲ positive status in comparison with IDC patients (P=۰.۰۲۳). The DFS and OS did not differ the between groups.Conclusion: MBC is a rare diagnosis with a favorable prognosis due to low lymph node metastases.

Authors

Sedigheh Tahmasebi

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Yasin Karami

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Majid Akrami

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Vahid Zangouri

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Azam Asgari

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Sara Hosseini

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Azin Sohrabi

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abdolrasoul Talei

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Nazanin Karimaghaei

Core Medical Trainee, Northumbria Healthcare NHS Foundation Trust, Newcastle upon Tyne, UK