Ali Ariafar - Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Shahryar Zeighami - Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mehdi Salehipour - Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Faisal Ahmed - Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra Shahabi - Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein-Ali Nikbakht - Social Determinates of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Background: Prostate cancer is a major malignancy worldwide among men; it is the fourth leading cancer in both genders. This study investigated the pathologic factors of radical prostatectomy (RP) specimens. Method: About ۵۷۸ men underwent RP during five years in Shiraz University hospitals. We recorded the following clincopathological parameters: tumor type and stage, Gleason score (GS), grade, tertiary pattern, ISUP, surgical margin, lymph node (LN) involvement, lymphovascular invasion, seminal vesicle involvement, extraprostatic extension (EPE), vas deferens invasion, perineural and pseudocapsular invasion, bladder neck involvement, and age. Results: The mean age of participants was ۶۳.۸۷ ± ۶.۹۵ years. Most had pathologic T۲N۰Mx (۷۳ %) diseases; the most GS was low-risk GS ≤ ۶ (۴۷.۴%). Surgical margin status was free of tumors in ۷۲.۵% and among those with positive margins; the most involved site was the apex in ۱۸.۳%. Single and dual LN involvements were the most prevalent patterns. ۵.۹% of the patients had EPE. We found perineural and pseudocapsular invasions in ۵۹.۹% and ۲۹.۹%, respectively. There was a strong correlation between the clincopathological parameters, stage, and ISUP. Perineural invasion, pseudocapsular invasion, and tertiary pattern ۵ increased with advanced age (P < ۰.۰۰۰۱). The GS ۸ to ۱۰ increased with the increase in age (P =۰.۰۰۱). Conclusion: A strong correlation existed between the clincopathological parameters, stage, and ISUP. Additionally, perineural and pseudocapsular involvement and tertiary pattern ۵ had a strong relationship with advanced age.

Prostate Cancer, Radical prostatectomy, Pathology