Alia Attia - Department of Radiation, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
Abeer Ibrahim - Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
Hussein Fakhry - Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt

Background: We conducted a retrospective analysis to evaluate the impact of omission of supraclavicular radiotherapy on supraclavicular failure rate and treatment outcomes in N۱ breast cancer patients with evaluation of prognostic factors that affected supraclavicular recurrence free survival.Methods: This study analyzed the medical records of ۱۰۹ patients with N۱ breast cancer. All patients underwent surgery and received adjuvant chemotherapy without supraclavicular radiotherapy. Supraclavicular recurrence free survival, distant metastasis free survival, disease free survival, and overall survival were estimated using the Kaplan-Meier method and compared using log-rank analysis.Results: After a median follow up period of ۵۸ months, treatment failed in ۳۱ patients (۲۸.۴%); patterns of failure consisted of locoregional (n=۲۱, ۱۹.۳%), isolated supraclavicular (n=۷, ۶.۴%), and distant metastasis (n=۱۴, ۱۲.۸%). Survival rates at ۵ years were as follows: supraclavicular recurrence free survival (۸۴.۹%), distant metastasis free survival (۸۷.۶%), and overall survival (۸۶.۴%). Univariate analysis revealed that the type of chemotherapeutic regimen was the only significant prognostic factor affected supraclavicular recurrence free survival; patients who received the cyclophosphamide, methotrexate, ۵-fluorouracil chemotherapy regimen experienced lower supraclavicular recurrence free survival than those who received doxorubicin based and taxane based chemotherapy. Development of supraclavicular recurrence significantly lowered the ۵-year overall survival (۵۷.۱%) and distant metastasis free survival (۵۰%) rates compared to patients without supraclavicular recurrence who had an overall survival rate of ۸۸.۵% (P<۰.۰۰۰۱) and distant metastasis free survival rate of ۹۰% (P<۰.۰۰۰۱).Conclusion: Patients with N۱ breast cancer had an overall supraclavicular recurrence of ۶.۴% which denoted that additional supraclavicular radiotherapy was unnecessary and could be given in N۱ patients after surgery and an adjuvant CMF regimen. A prospective randomized trial would be needed to clarify the impact of supraclavicular radiotherapy on treatment outcome.