Abdolazim Sedighi Pashaki - Mahdieh Department of Radiation Oncology, Hamadan, Iran
Ehsan Akbari Hamed - Mahdieh Department of Radiation Oncology, Hamadan, Iran
Kamal Mohammadian - Mahdieh Department of Radiation Oncology, Hamadan, Iran
Mohammad Abbasi - Hamadan University of Medical Sciences, Hamadan, Iran
Afsane Maddah Safaei - Tehran University of Medical Sciences, Tehran, Iran
Mohammad Babaei - Tehran University of Medical Sciences, Tehran, Iran
Mohamamad Hadi Gholami - Physicist, Mahdieh Department of Radiation Oncology, Hamadan, Iran
Alireza Khoshghadam - Physicist, Mahdieh Department of Radiation Oncology, Hamadan, Iran

Background: Central nervous system tumors account for ۲%-۵% of all malignancies in humans. These tumors account for ۲% of all pediatric cancers. The worldwide incidence of primary central nervous system tumors is estimated at ۳.۹ (males) and ۳.۲ (females) per ۱۰۰۰۰۰ person-years. The incidence of brain tumor cases has been reported as ۳.۶۷% of all malignancies and ۴% of all cancer mortalities in Iran. The five most common histological types of brain tumor in Iran according to different case studies are; meningioma, astrocytoma, glioblastoma, pituitary adenoma and ependymoma. The aim of this study is to determine the histopathological pattern and characteristics of patients with brain tumors who have referred to the Mahdieh Radiotherapy Department, Hamadan, Iran. Methods: This descriptive, retrospective study was performed at the Mahdieh Radiotherapy Department, between ۲۰۰۵ and ۲۰۱۲. We included ۲۲۰ patients who referred to the Radiotherapy Department with diagnoses of primary brain tumor in this study.Results: Between ۲۰۰۵ and ۲۰۱۲, we treated ۲۲۰ new cases of primary brain tumor at Mahdieh Radiotherapy Department. The mean age at diagnosis was ۳۹.۹۵±۱۵.۴۸ years with a median age of ۳۹ years. Patients' ages ranged from ۴ to ۷۵ years. Among the ۲۲۰ patients, ۱۳۸ were male and ۸۲ were female with a male to female ratio of ۱.۶۸. For most tumors there was a male predominance, with the exception of meningioma (M/F: ۰.۲۳), ependymoma (M/F: ۱) and pituitary adenoma (M/F: ۰.۶). Astrocytomas, glioblastomas, high grade meningiomas and oligodendrogliomas were the four most common pathologies treated in this department. The best treatment results were achieved in patients with astrocytomas.Conclusion: The present study is a retrospective radiotherapy centre-based study designed in a pioneer radiotherapy centre in Western Iran, not a prospective population study. These data have provided a baseline for further epidemiological studies. Our encouraging results in radiotherapy treatment of primary malignant tumors clearly highlight the benefits of definitive or postoperative radiation.