Shapour Omidvari - Associate Professor of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Hamid Nasrolahi - Radiation Oncologist, Shiraz University of Medical Sciences, Shiraz, Iran
Mansour Ansari - Assistant Professor of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Niloofar Ahmadloo - Associate Professor of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Ahmad Mosalaei - Professor of Radiation Oncology, Shiraz University of Medical Sciences, Cancer Research Center, Shiraz, Iran
Mohammad Mohammadianpanah - Associate Professor of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

Basal cell carcinoma (BCC) is the most common cancer among humans, and the standard treatment is surgery. Other modalities are reserved as a second line of treatment. Topical chemotherapy may be used in primary BCC. Systemic chemotherapy has no role in the primary treatment of BCC, although it may be efficacious in metastatic cases. We report the case of a patient with persistent recurrent BCC following multiple surgeries and radiotherapy, who achieved a dramatic response with a cisplatin and ۵-flourouracil chemotherapy regimen.