Hua Zhang - Department of Animal Science, College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China‎
Jin-jin Tong - Department of Animal Science, College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China‎
Zhao-Nan Zhang - Department of Animal Science, College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China‎
Hong-Bin Wang - Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China‎
Yong-Hong Zhang - Department of Animal Science, College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China‎

This study describes a left hemihepatectomy combined with a right lateral hepatic lobectomy. It compares the inflammatory response associated with laparoscopic hepatectomy (LH group, n = ۷) with conventional open hepatectomy (OH group, n = ۷). Blood was collected before surgery as well as ۱, ۲, ۳, ۵, and ۷ days after surgery to determine the white blood cell count and levels of serum cortisol (COR), interleukin-۶ (IL-۶), and C-reactive protein (CRP). The left hemi-hepatectomy combined with a right lateral hepatic lobectomy was completed in miniature pigs. The average operative time was ۱۳۹.۰۰ ± ۹.۰۷ min, which was longer than that in the OH group (۱۲۱.۶۷ ± ۳.۰۲ min). The length of surgical incision associated with the OH group was ۱۷.۹۳ ± ۱.۰۹ cm, significantly longer than that related to the LH group (۵.۱۰ ± ۰.۱۷ cm). The estimated mean blood loss in the LH group was ۱۳۶.۴۳ ± ۶۳.۲۴ mL, which was significantly lower than that in the OH group. No severe complications (e.g., massive bleeding, bile leakage, and air embolism) were reported. The CRP levels, COR, and IL-۶, increased significantly in the OH group and then slowly returned to their preoperative levels. A postoperative laparoscopic exploration revealed that the incised portion of the liver adhered to the omentum, but no additional abnormalities were observed. These findings indicate that a ۴-trocar method for laparoscopic left hemihepatectomy combined with a right lateral hepatic lobectomy is safe and feasible. The inflammatory response for those receiving LH are lower than that for those receiving OH. This porcine model can be used as a research analog for liver disease and regeneration.

Extensive hepatectomy, ‎Inflammatory response, laparoscopy, Pigs