Nahid Ramezani-Jolfaie - Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Mojtaba Khademi Bafrooei - Department of Internal Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Elnaz Lorzadeh - School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW ۲۵۲۲, Australia
Gholamali Javdan - Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Farkhondeh Razmpour - Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Alireza Shahab Jahanlou - Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran;
Amin Salehi-Abargouei - Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Mohammadi - Food Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Background: Although some studies have reported that flavonoids can be associated with anti-obesity effects, the putative effects of hesperidin, as a subgroup of flavonoids, on anthropometric parameters are inconclusive. Therefore, this systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of hesperidin supplementation on anthropometric measures in adults. Methods: A comprehensive literature search was performed until February ۲۰۲۲ in electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar. The pooled results were obtained by a random-effects model. Results: A total of nine RCTs enrolling ۴۹۳ participants were identified. Seven studies had illustrated the effect of hesperidin on weight, eight on body mass index (BMI), five on waist circumference (WC), two on waist to hip ratio (WHR), and two on hip circumference (HC). The results of the pooled analysis showed no significant changes in body weight (۰.۰۱ kg, ۹۵% CI: -۰.۲۲, ۰.۲۴), BMI (-۰.۰۲ kg/m۲, ۹۵% CI: -۰.۱۶, ۰.۱۳), and WC (-۰.۴۸ cm, ۹۵% CI: -۱.۵۲, ۰.۵۵) after hesperidin supplementation compared to the control group (P > ۰.۰۵). Qualitative assessment of other anthropometric indices also showed no beneficial effect of hesperidin in reducing WHR and HC values; however, these findings are not conclusive because of the limited number of studies. Conclusion: The present study provides no evidence that hesperidin supplementation is effective in improving anthropometric measures. More high-quality RCTs especially among overweight and obese individuals are needed to strengthen the evidence. Corresponding Author:Mohammad Mohammadi View Orcid in Profile You can search for this author in PubMed     Google Scholar Profile

Hesperidin, Body weight, Anthropometry, Systematic review, Meta-analysis