Arief Fatkhur Rohman - Master of Pharmacy Study Program, University of Indonesia, Depok, Indonesia
Maksum Radji - Laboratory of Microbiology, Department of Pharmacy, University of Esa Unggul, Jakarta
Alfina Rianti - Pharmacy Installation, Fatmawati General Hospital, Jakarta, Indonesia
Arif Rachman - Department of Cell Biology and Biomolecular, Faculty of Medicine, Indonesian Defense University, Bogor, Indonesia

Background: High use of antibiotics in sepsis patients can lead to irrational use of antibiotics. Irrational antibiotic therapy in septic patients in the ICU increases the mortality rate in the hospital. Efforts to maximize the rational use of antibiotics are one of the pharmacist's responsibilities.Aim: This study aims to evaluate the quality and quantity of antibiotic use in sepsis patients in the Intensive Care Unit (ICU) ward using the Gyssens and ATC/DDD methods and to evaluate the effect of pharmacist intervention in improving the quality of antibiotic use and therapeutic outcomes.Materials and methods: The research was carried out prospectively during the period of August-November ۲۰۱۸ using a one-group pretest-posttest pre-experimental study design. Recommendations are given to prescribers regarding the problem of inappropriate use of antibiotics.Result: Qualitative evaluation using the Gyssens method found that rational use of antibiotics in sepsis patients was ۸۵.۱% and ۱۴.۹% were irrational. The interventions increased the accuracy of the use of antibiotics (۰% to ۶۴.۷%), reduced the problem of choosing antibiotics (۸۸.۲% to ۳۲.۴%), the problem of the duration of antibiotic administration (۵.۹% to ۰%) and the problem of the route of administration of antibiotics (۵.۹% to ۰%). The results of the quantitative evaluation obtained the value of the use of antibiotics, namely ۶۳.۸ DDD/۱۰۰ days of treatment, with the greatest value for meropenem antibiotics, namely ۳۲.۹ DDD/۱۰۰ days of treatment.Conclusion: There are differences in the therapeutic results between the quality of rational use of antibiotics and the quality of irrational use of antibiotics in the ICU ward of Fatmawati Hospital.

Evaluation of antibiotics, Sepsis, Gyssens criteria, ATC/DDD