P. Powthong - Faculty of Medical Technology, Rangsit University, Pathumthanee, ۱۲۰۰۰, Thailand.
B. Jantrapanukorn - Faculty of Medical Technology, Rangsit University, Pathumthanee, ۱۲۰۰۰, Thailand.
A. Thongmee - Department of Medical Sciences, Faculty of Science, Rangsit University, Pathumthanee, ۱۲۰۰۰, Thailand
P. Suntornthiticharoen - Department of Medical Sciences, Faculty of Science, Rangsit University, Pathumthanee, ۱۲۰۰۰, Thailand

The purpose of this research was to study the antimicrobial activities of the endophytic fungi from Sesbania grandiflora (L.) Pers. The endophytic fungi were isolated from branches and leaves of Sesbania grandiflora (L.) Pers., and sixty nine isolates were obtained. All isolates were screened for antibacterial and antifungal activities. The indicator organisms were ۴ bacteria including Staphylococcus aureus ATCC ۲۵۹۲۳, Bacillus subtilis ATCC ۶۶۳۳, Escherichia coli ATCC ۲۵۹۲۲ and Pseudomonas aeruginosa ATCC ۲۷۸۵۳, two yeasts, namely, Candida albicans and Cryptococcus neoformans, and ۶ molds including Rhizopus spp., Mucor spp., Penicillium spp., Aspergillus spp., Curvularia spp.,and Alternaria spp.. It was found that ۲۸ and ۱۶ isolates showed antibacterial activity against gram positive and gram negative bacteria, respectively. Also, ۱۱ and ۱۷ isolates showed antifungal activity against yeasts and hyaline non-septate hyphae, respectively. Besides, ۱۳ and ۶۵ isolates showed antifungal activity against hyaline septate and dematiaceous, respectively. There were ۹ isolates that could inhibit bacteria, yeast, and molds. Macroscopic and microscopic examination of the fungal morphology revealed that most of the endophytic fungi (۲۵ isolates) were hyaline septate hyphae. Only ۳ isolates were hyaline non-septate hyphae. Fusarium spp. and Acremonium spp. were the predominate species among the isolated endophytic fungi. These results indicated that some endophytic fungi isolated from Sesbania grandiflora (L.) Pers. were potential sources of antimicrobial compounds against the tested bacteria, yeasts, and molds.

Antifungal activity, Bioactive compounds, Co-evolution relations, host plants