Monir Al-sadat Mirrahimi - Department of Chemistry, Faculty of Science, University Zanjan, Zanjan, Iran
Abbas Bahari - Department of Biotechnology , Research Institue of Modern Biological Techniques(RIMBT),University Zanjan, Zanjan, Iran
Hashem Shahroosvand - Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran

Recently, researchers have focused to the synthesis of nanomaterials with extraordinary wonders to treat and diagnosediseases. These substances, which are called upconversion, have special characteristics that can have the least negative impact andthe greatest depth of penetration on the tissues and cells of the body. In this research, we synthesized transforming materials, whichhad the ability to affect tumors with unique optical properties and due to the possibility of stimulation, in the infrared range, thecondition of certain biological studies, with the least amount of damage to the tissues. In this wavelength provided [۱]. In thisresearch, various types of cubic, spindle like [۲] and hexagonal structures of biocompatible upconversion were synthesized byhydrothermal method and identified by different detection methods such as XRD, TEM, PL, FTIR, UV-VIS. The identificationresults were in good agreement with the reference templates and their effects on MCF۷ breast-derived cell lines were evaluatedthrough Annexin PI and MTT assays. These NaYF۴ nanomaterials were combined with activator and sensitizer ions and theireffects on breast cancer cells were investigated by flow cytometry and MTT analysis. This study will contribute to the developmentof new nanomaterials with promising biomedical applications[۳] and provide new avenues for advanced diagnostic and therapeuticinterventions. Synthetic nanoparticles were a good option for use in biological studies due to the appropriate intensity of emissionradiation, optical stability under appropriate stimulation.

Upconversion, Hexagonal, toxicity, Flow cytometry