Arash Letafati - Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Omid Salahi - Research Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran.
Seyed Mohammad Jazayeri - Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Azam Ghaziasadi - Research Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran.
Tannaz Sakhavarz - Research Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran.
Mina Soleimani - Research Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran.
Yeganeh Goldoost - Research Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran.
Mehdi Norouzi - Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Human Papillomaviruses (HPVs) are common sexually transmitted viruses that cause health problems, including genital warts and different type of cancers. There are over ۲۰۰ different types of HPV, some of which are correlated with the progress of cervical cancer. One of the HPV genes responsible for its oncogenic potential is the E۶ gene. E۶ is a critical protein in the life cycle of HPV and a key contributor to the development of HPV-associated cancers. Its interactions with cellular proteins lead to disruptions in key cellular pathways and the promotion of cancerous cell growth. Overall, HPV E۶ represents a reassuring target for the expansion of novel therapies for the treatment of HPV-associated cancers and understanding its molecular interactions with host proteins is critical for developing targeted therapies for HPV-associated cancers. In this article, we will focus on the cancer-related mechanism and cell interaction of HPV E۶.

Cancer, Viruses, Tumor suppressors, HPV, Cervical cancer, HPV E۶