Farhad Abolhassan Choobdar - Department of Neonatology, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.
Hani Milani - Department of Neonatology, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran.
Kamran Behrouzi - Department of Neonatology, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran.
Nasrin Khalesi - Department of Neonatology, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.
Behzad Haghighi - Department of Pediatric Intensive Care, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.
Ali Manafi - Department of Pediatric Intensive Care, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Naderisorki - Thalassemia Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Sorraya Shojaee - Department of Neonatology, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: ABO/Rh incompatibilities are common causes of hemolytic disease of newborn. Alloimmunization due to minor RBC antigens may also cause severe hemolysis and hyperbilirubinemia necessitating exchange transfusion in the early neonatal period. Case Presentation: Here we report a rare case (first such report to our knowledge in Iran) of severe hemolytic disease of the newborn due to anti-Rh۱۷ antibody (an antibody to the RhCc/Ee antigen protein) in a newborn with maternal blood group B Rh D--. Conclusion: Presenting this case would improve the insight and knowledge about managing severe hemolytic anemia due to minor group alloantibodies postnatally, and highlight the importance of prenatal surveillance and diagnosis for the optimal management of alloimmune hemolytic disease.

Anti-Rh۱۷, Minor blood groups, Rh Isoimmunization, Hemolysis, Newborn, Hyperbilirubinemia