Stem Cell Therapy in Children With Sensorineural Hearing Loss: A Narrative Review

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JPRE-9-3_004

تاریخ نمایه سازی: 9 آذر 1402

Abstract:

Context: One of the research areas is using stem cell transplantation for treating children’s sensorineural hearing loss. Preclinical studies and testing of the stem cell types have been performed in this field, and relative improvement has been achieved.  Objectives: This narrative review has been prepared to study the advancements in hearing regeneration with stem cell transplantation. Data Sources: The English articles with full-text were searched in PubMed, Scopus, and Google scholar from ۲۰۰۰ to ۲۰۲۰ using keywords of sensory neural hearing loss and stem cell. Results: In ۲۰۱۸, the first human study was performed with stem cells from the human umbilical cord, which has promising results regarding the safety of the method and its positive effects on hearing. Conclusions: Autologous stem cell transplantation had induced relative improvement without serious adverse events in children with acquired sensorineural hearing loss. To obtain more evidence, further studies are required with larger sample sizes and in different patients groups.

Authors

Mahbobeh Oroei

Department of audiology, rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran , Iran.

Mohsen Ahadi

Department of audiology, rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran , Iran.

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