Newsha Hedayati - Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
Vida Mortezaee - Student Research Committee, Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Seyed Alireza Mahdaviani - Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Maryam Sadat Mirenayat - Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Maryam Hassanzad - Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mihan Pourabdollah - Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Jalal Heshmatnia - Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Atefeh Fakharian - Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Guitti Pourdolat - Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NIRTLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Somayeh Sharifynia - Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mahshid Vakili - Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Mahdi Abastabar - Invasive fungi research center, Mazandaran University of Medical Sciences, Sari, Iran
Iman Haghani
Masoud Aliyali
Hossein Asgarian-Omran - Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Mohammad T. Hedayati - Invasive fungi research center, Mazandaran University of Medical Sciences, Sari, Iran

Background and Purpose: Aspergillus fumigatus as a ubiquitous fungus can be found in the respiratory tract of the asthmatic and healthy people. The inhalation of Aspergillus spores leads to an immune response in individuals with asthma and results in the aggravation of the clinical symptoms. The present study aimed to investigate the prevalence of specific immunoglobulin E and G (IgE and IgG) against A.fumigatus in asthmatic patients. Materials and Methods: This study was conducted on ۲۰۰ consecutive patients with moderate to severe asthma referring to Masih Daneshvari hospital Tehran, Iran, from January ۲۰۱۶ to February ۲۰۱۸. Skin prick test (SPT) was performed in all subjects with Aspergillus allergens. Moreover, all patients underwent specific IgE testing for Aspergillus using Hycor method. Enzyme immune assay was applied to measure total IgE and Aspergillus-specific IgG. Results: According to the results, the mean age of the patients was ۴۵.۸ years (age range: ۱۸-۷۸ years). The mean levels of total IgE and Aspergillus specific IgE in asthmatic patients were obtained as ۳۱۶.۳ (range: ۶-۱۳۰۰ IU/ml) and ۱.۵ (range: ۰.۱- ۶۱.۳ IU/ml), respectively. Out of ۲۰۰ patients, ۲۷ (۱۳.۵%), ۶۵ (۳۲.۵%), ۲۲ (۱۱.۰%), and ۸۶ (۴۳.۰%) cases had positive Aspergillus SPT, total IgE of > ۴۱۷ IU/ml, Aspergillus-specific IgE, and IgG, respectively. The level of these variables in patients with severe asthma were ۱۶ (۱۶.۵%), ۳۶ (۳۷.۱%), ۱۵ (۱۵.۵%), and ۴۶ (۴۷.۴%), respectively. Conclusion: As the findings indicated, reactivity to Aspergillus is a remarkable phenomenon in asthmatic patients. It is also emphasised that the climatic condition may affect the positive rate of hypersensitivity to Aspergillus.

Aspergillus fumigatus, Asthmatic patients, Specific IgE, Specific IgG