Mina Jazaeri - Assistant Professor of Oral Medicine, Department of Oral Medicine, Dental Research Center, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
Sahrbanoo Radi - Oral Medicine Specialist, Private Practice
Mehrdad Hajilooi - Associate Professor of Medical Immunology, Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Ali Seifrabiei - Associate Professor of Community Medicine, Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Background: According to the high prevalence of iron (Fe) deficiency anemia, it is highly important to reach simple and cost-effective methods for accurate diagnosis. Considering that saliva, as a diagnostic substance is of great value, the present study aimed to compare the amount of salivary Fe and total ironbinding capacity (TIBC) levels of patients with Fe deficiency anemia and healthy individuals. Methods: In this descriptive-analytic cross-sectional study, thirty ۲۰-۴۰-year-old women participated in case (patients with anemia) and control (healthy individuals) groups. After collecting the serum and saliva samples of each participant, Fe and TIBC levels were measured in μg/dL. Data were analyzed using SPSS with Kolmogorov-Smirnov, t test and Pearson correlation tests at the significant level of ۰.۰۵. Results: The mean age of the participants of the case and control groups was ۳۱.۲۵ and ۳۰.۶, respectively. The average amounts of salivary Fe and TIBC of patients with Fe deficiency were ۲۸.۶۰ and ۶۱۰.۰۰ μg/dL, respectively. Further, the means of salivary Fe and TIBC of the control group were ۷۸.۸۰ and ۲۹۰.۰۰ μg/dL, respectively. Based on the results, the serum Fe and TIBC of anemic patients were ۲۷.۰۵ and ۵۸۹.۷۰ μg/ dL, whereas the means of the serum Fe and TIBC of the control group were ۸۰.۲۷ and ۲۸۶.۸۰, respectively. There were significant differences between both salivary and serum values of the Fe and TIBC of case and control groups (P < ۰.۰۵). Furthermore, the relationship between the serum and salivary levels of Fe and TIBC were positive and significant (P < ۰.۰۵). Conclusions: Based on the results of the present study, significant changes were found in the salivary amount of the Fe and TIBC of patients with Fe deficiency anemia corresponding to the serum levels of Fe and TIBC, thus saliva could be considered as a diagnostic substance for the detection of Fe deficiency anemia.

Iron, Anemia, Serum, Total iron-binding capacity