Fatemeh Najatifar - Department of Hematology and Oncology, Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, Iran
Habib Zayeni - Department of Rheumatology, Guilan University of Medical Sciences, Rasht, Iran
Marjan Yaghmaie - Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
Narges Akrami - Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Gastrointestinal stromal tumors are the most common mesenchymal tumor of the alimentary canal. Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia. A ۵۷-year-old male patient with a previous record with history of gastrointestinal stromal tumors (GIST) and ankylosing spondylitis, was hospitalized with right ankle and foot swelling and pancytopenia. A diagnosis of APL was made by bone marrow aspiration and cytogenetic study. After a combined treatment with all-trans retinoic acid and arsenic trioxide, the patient achieved cytogenetic and molecular remission. According to past studies, the synchronous or metachronous coexistence of GISTs with other malignancies, such as lymphoma, liver cancer and pancreatic tumors has been widely reported. This study describes a patient with the metachronous occurrence of a CD۳۴ positive GIST and APL. We suggest, the minor alterations in hematological parameters must be taken into consideration for such cases.

GIST, Acute promyelocytic leukemia, Ankylosing spondylitis, HLAB۲۷