Younes Qasempour - Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Neda Neda - Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hashem Khanbabaei - Assistant Professor, Department of Radiologic Technology, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran

Radiomics, a burgeoning field at the intersection of radiology, oncology, and data science, has gained substantial attention in recent years. With the advent of advanced medical imaging technologies, radiomics offers a novel approach to extract quantitative data from medical images, enabling the transformation of images into mineable data repositories. This data-driven paradigm shift has the potential to revolutionize clinical decision-making in oncology.This article provides a comprehensive overview of radiomics, its methodologies, and its applications in oncology. We delve into the underlying principles of feature extraction, selection, and modeling techniques, highlighting the significance of radiomic features in characterizing tumor heterogeneity. Radiomics' ability to unravel hidden patterns within medical images is discussed, showcasing its potential to aid in early diagnosis, treatment response prediction, and prognostication.Furthermore, we explore the integration of radiomics with genomics, termed radiogenomics, and its role in unraveling the intricate relationship between imaging phenotypes and genomic alterations. Radiogenomics opens new avenues for personalized medicine by elucidating the genetic basis of radiomic features and their implications in tailoring therapeutic strategies.In this article, we also address the challenges and limitations of radiomics, including data standardization, model generalizability, and clinical translation. We emphasize the need for rigorous validation and collaboration between radiologists, oncologists, and data scientists to harness the full potential of radiomics in clinical practice.In conclusion, radiomics stands as a promising frontier in oncology, offering a non-invasive and quantitative approach to decipher the complex landscape of tumors. By bridging the gap between medical imaging and precision medicine, radiomics holds the key to unlocking new insights into tumor biology and guiding more effective, personalized treatment strategies.