Systemic Inflammation Biomarkers Ratio as Predictors of Clinical Outcomes in Ischemic Stroke

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_CJNS-9-4_001

تاریخ نمایه سازی: 29 آذر 1402

Abstract:

Background: Strokes are among the major causes of disabilities worldwide. In recent years, there has been considerable interest in evaluating stroke prognoses. Objectives: In this investigation, we studied the association of lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and ESR-CRP ratio (ECR) with ۳ months outcomes among those with acute ischemic stroke (AIS). Materials & Methods: We carried out the present cross-sectional investigation among AIS patients at an academic hospital in northern Iran (from ۲۰۱۹ to ۲۰۲۱). Within ۲۴ hours after the onset of symptoms, laboratory and clinical data of the patients were obtained. We assessed the results using the modified rankin scale (mRS) ۹۰ days after the initial assessment. Statistical significance for comparing descriptive data was determined as P<۰.۰۵. Results: We entered ۳۴۱ participants (Mean±SD age: ۶۹.۱۰±۱۳.۵۵ years, ۵۳.۱% female) into this investigation. Based on univariate analysis, there were poor correlations between NLR (r=۰.۳۶۱, P<۰.۰۰۱), PLR (r=۰.۲۱۵, P<۰.۰۵), CRP (r=۰.۲۳۴, P<۰.۰۰۱), LMR (r=-۰.۱۸۴, P<۰.۰۵), and ECR (r=-۰.۱۹۱, P<۰.۰۵) and a ۳-month mRS. Also, after three months, the NLR, PLR, and CRP values were higher in the patients who died, but the LMR (P<۰.۰۰۱) and ECR (P<۰.۰۵) were lower. In multivariate comparison, only ECR was independently higher among the participants who died within ۳ months (P<۰.۰۵). Conclusion: In this study, ECR within ۲۴ hours of symptoms onset was related to functional outcomes and mortality at ۳-month follow-up. Thus, ECR might provide valuable prognostic information at a relatively low cost.

Authors

Arman Keymoradzadeh

Department of Neurosurgery, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Alia Saberi

Department of Neurology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran

Armin Soleymanpour

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Iran

Amirhossein Roshan

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Iran

Parastoo Mohammadi

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Iran

Arash Bakhshi

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Iran