Rahimeh Hajinasiri - Chemistry Department, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

An efficient method is described to generation of pyrido[۲,۱-a]isoquinoline-۳,۴-dicarboxylates via one-pot four-component reaction of dialkyl acetylenedicarboxylate, isoquinoline, aldehydes and malononitrile (or dimedone) catalyzed by CuO-NPs. This reaction is performed in gently conditions with good yield.

Pyrido[۲,۱-a]isoquinoline-۳,۴-dicarboxylate; Four-component reactions; Isoquinoline; Dialkyl acetylenedicarboxylate; Huisgen intermediate; Dimedone; CuO-NPs