Mohammad Ehsan Mohammadi-Arani - Biomaterial and Medicinal Chemistry Research Center, Aja University of Medical Science, Tehran, Iran
Ramin Zibaseresht - Department of Chemistry (Christchurch) and Department of Chemistry and Physics, University of Canterbury and Maritime University of Imam Khomeini, Tehran, Iran
Mohsen Chamanara - Toxicology Research Center, Aja University of Medical Sciences, Tehran, Iran
Reza Mosaed - Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran
Mohammad Mahboubi-Rabbani - Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Maryam Bayanati - Department of Food Technology Research, National Nutrition and Food Technology Research Institute/Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hossein Fasihi - Biomaterial and Medicinal Chemistry Research Center, Aja University of Medical Science, Tehran, Iran

The present review aims to examine the use of carbamazepine (CBZ) in plasma based on various techniques, such as high-performance liquid chromatography (HPLC) and chromatographic analysis. The review considered in this research is narrative, which is based on previous studies. The effects of CBZ in treating seizures and epilepsy are investigated comprehensively. Accordingly, the related studies regarding the effects of CBZ in plasma based on HPLC were investigated in detail. Due to the findings given in the previous studies, it was revealed that the effects of CBZ are positive and negative for people's health. Due to the obtained results, micellar electro-kinetic chromatography (MEKC) is used for specifying CBZ. Furthermore, the benefits of single reference HPLC are well documented in the literature for therapeutic drug monitoring (TDM) of phenytoin (PHT) and CBZ in plasma. Notably, the use of metal analysis was useful for indicating the positive effect of CBZ in the epilepsy treatment. The combination of chlorpromazine (CPZ) with other drugs can prevent its adverse effects and make it more popular in medicine. The prevention of seizure progression and epilepsy using the CBZ and its counterparts is still a controversial issue that should be tackled in the future.

carbamazepine, TDM, High-performance liquid chromatography, Bipolar disease, Seizure treatment