Mohaddeseh Rostampourgonbaki - Faculty of Rehabilitation, Babol University of Medical Sciences, Babol, Iran.
Niloofar Deghanpour - Faculty of Rehabilitation, Babol University of Medical Sciences, Babol, Iran.
Keivan Kiakojouri - Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Mehdi Dehghan - Ayatollah Rouhani Clinical Research Center, Movement Disorders Research Center, Faculty of Rehabilitation, Babol University of Medical Sciences, Babol, Iran.
Hemmat Gholinia - Clinical Research Center of Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.

Objectives: The present study aims to compare acoustic voice parameters in patients with vocal cord nodules, polyps, and normal subjects.  Methods: In this cross-sectional case-control study, the participants were selected by convenience sampling, including ۳۰ patients with vocal polyps for the first group, ۳۸ patients with vocal nodules for the second group, and ۴۲ participants without voice pathologies as the control group. For each group, participants were examined by a speech and language pathologist (SLP) using an Endo-vision laryngoscope. Acoustic voice parameters were measured by MDVP software in Visi-Pitch; then, these parameters were compared in groups in terms of sex. Results: Three groups showed significant differences in terms of fundamental frequency (P<۰.۰۰۱), jitter (P<۰.۰۰۱), shimmer (P<۰.۰۰۱), and noise-to-harmonic ratio (NHR) values (P<۰.۰۰۱). Women in three groups had the substantial differences in terms of fundamental frequency (P<۰.۰۰۱), jitter (P<۰.۰۰۱), shimmer (P<۰.۰۰۱), and NHR (P<۰.۰۰۱). For men, the three groups showed a significant difference for jitter (P<۰.۰۰۱) and shimmer (P=۰.۰۰۱), but for NHR (P=۰۲۴), and fundamental frequency (P=۰.۹۳) no signification difference were observed.  Discussion: It seems that the existence of benign mass lesions, such as vocal cord nodules and polyps affects the acoustic parameters of the voice. The measurement of acoustic voice parameters may help us to differentiate between the voices of normal people and patients with vocal cord nodules and polyps as a supplementary assessment in clinical procedures.

Vocal fold polyps, Vocal nodule, Acoustic parameters, Voice analysis, Multi-dimensional voice program