Mehdi Kian - Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Ranjbar-Zahedani - Department of Nutrition Sciences, School of Health, Larestan University of Medical Sciences, Larestan, Iran
Mehdi Bonyani - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Hadis Asadimehr - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Mehran Nouri - Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Bakhtiari - Behbahan Faculty of Medical Sciences, School of Medical Sciences, Behbahan, Iran
Sasan Amanat - Department of Nutrition Sciences, School of Health, Larestan University of Medical Sciences, Larestan, Iran

Background: Dyslipidemia puts patients at risk of cardiovascular diseases, which are the most cause of premature deaths worldwide. This study determined protective effects of resveratrol (RVL) and atorvastatin (ATV) in rats fed with a high-fat/high-fructose (HFHF) diet were compared for e treatment of atherogenic dyslipidemia.Methods: Thirty-six adult male Sprague Dawley rats were divided into ۴ groups, including a group fed with a standard diet and three groups fed with a HFHF diet for ۱۲ weeks. In two groups, in addition to HFHF diet, animals received RVL (۱۰۰ mg/kg) and ATV (۱۰ mg/kg) by gavage. After ۱۲ weeks, levels of body and heart weights, systolic blood pressure(SBP), serum biomarkers of atherogenic dyslipidemia, insulin resistance, and malondialdehyde (MDA) in the heart tissue were measured.Results: Rats received the HFHF diet showed an elevation (p<۰.۰۵) in body and heart weight, SBP, serum total triglycerides (T-TGs), total cholesterol (T-CHOL), low-density lipoprotein CHOL (LDL-C), insulin resistance, aspartate aminotransferase (AST), and tumor necrosis factor- alpha (TNF-α), and also, elevated MDA content in the heart tissue. The administration of RVL significantly reduced (p<۰.۰۵) heart weight, SBP, serum T-TGs levels, insulin resistance, TNF-α, and cardiac MDA in rats received HFHF diet. On the other hand, the administration of ATV significantly decreased (p<۰.۰۵) heart-weight, and serum levels of T-TGs, T-CHOL, LDL-C, and TNF-α.Conclusion: RVL at a dose of ۱۰ mg/kg was not a better protective medication against atherogenic dyslipidemia; but it may be applicable as a complementary medication with ATV.

Dyslipidemia, Resveratrol, Atorvastatin, Rat