Ahmad Amouzeshi - Associate Professor of Cardiovascular Surgery, Department of Surgery, School of Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
Asghar Zarban - Associate Professor of Clinical Biochemistry, Department of Clinical Biochemistry, School of Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
Maryam Khodabakhshi - Master in Nursing Education, Birjand University of Medical Sciences, Birjand, Iran

Introduction: Appendicitis is a challenging condition for emergency specialists and surgeons to diagnose. If it is not treated in time, the inflamed tissue of the appendix ruptures, causing peritonitis and shock. This study evaluated the diagnostic value of clinical and laboratory symptoms in the diagnosis of acute appendicitis. Methods: This descriptive cross-sectional study was carried out on a total of ۱۳۴ patients with suspected appendicitis referring to the Emergency Department of Imam Reza Hospital in Birjand, Iran, within ۲۰۱۳ and ۲۰۱۵ using convenience sampling. The data collection tool was a questionnaire covering patients’ demographics, clinical signs, and laboratory and pathology test results. Sensitivity and specificity, positive predictive value, negative predictive value, likelihood ratio, area under the receiver operating characteristic (ROC) curve (AUC), and cut-off point of each test (i.e., white blood cell, aspartate transaminase, alanine transaminase, C-reactive protein, polymorphonuclear leukocytes, lymphocytes, total and direct bilirubin, iron, and total iron-binding capacity) were analyzed using SPSS software (version ۱۸) and MedCalc software (version ۱۹). A p-value of ۰.۰۵ was considered statistically significant. Results: In this study, ۶۸ and ۶۶ participants were male and female, respectively. The mean age of the patients was ۲۴. (۴۴±۱۱).۲۶ years. Pathological examination showed that six patients underwent a negative appendectomy. A positive appendectomy was noted in ۱۲۸ subjects. Histopathological results confirmed the perforation of the appendix in ۷۸ patients. Among the laboratory tests, only the accuracy of serum iron was fair in the diagnosis of acute appendicitis (AUC numerical value in the ROC curve=۰.۷۸۷). The accuracy of other tests based on the AUC numerical value in the ROC curve was poor or failed. Conclusions: Although the accuracy of serum iron based on the numerical value of AUC in the ROC curve was diagnostically fair for acute appendicitis, it is suggested to carry out further studies with larger sample sizes in order to draw definitive conclusions given the small sample size in this study.

Appendicitis, Diagnosis, Signs and Symptoms