M. R Nourani - Genomics Division, Systems Biology Institute, Tissue Engineering Division, Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
A Kalantari Hesari - Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran
R Shahrooz - Professor of Histology and Embryology, Department of Basic Science, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
M. R Asadi - Assistant Professor of Histology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran

The present study aimed to assess the effect of tissue hypoxia induced by sodium cyanide (NaCN) on male mice fertility and the protective role of ethyl pyruvate (EP). A number of ۳۰ adult mice were assigned to three groups: ۱) a control group, ۲) a treatment group treated with ۲ mg/kg of NaCN, and ۳) a treatment group treated with ۲ mg/kg of NaCN, along with ۴۰ mg/kg EP (NaCN+EP). After ۳۵ days, animals were anesthetized and serum, sperm, and tissue samples were taken. The results demonstrated a significant decrease in sperm quality, reproduction potency, and anti-oxidant potential, as well as an increase in lipid peroxidation in the NaCN group (p <۰.۰۵). Moreover, the use of EP effectively restrained the disastrous effects of tissue hypoxia. It can be concluded that EP can moderate the complications resulting from tissue-hypoxia that is related to testes parameters.

ethyl pyruvate, Cyanide, Mice, reproduction potency, sodium, tissue hypoxia