Malathion-increased Hepatotoxicity in Diabetic Rats
عنوان مقاله: Malathion-increased Hepatotoxicity in Diabetic Rats
شناسه ملی مقاله: JR_PBRE-6-1_006
منتشر شده در در سال 1399
شناسه ملی مقاله: JR_PBRE-6-1_006
منتشر شده در در سال 1399
مشخصات نویسندگان مقاله:
Seyedeh Azam Hosseini - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Ahmad Ahmadipour - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Motahareh Soltani - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad Mehdipour - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Ali Mandegary - Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Somayyeh Karami-Mohajeri - Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
خلاصه مقاله:
Seyedeh Azam Hosseini - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Ahmad Ahmadipour - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Motahareh Soltani - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad Mehdipour - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Ali Mandegary - Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Somayyeh Karami-Mohajeri - Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Background: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus.
Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats.
Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of ۱۵۰ mg/kg/day orally. After ۲۸ days, fasting blood glucose, Glucose Tolerance Test (GTT), serum aminotransferases, and liver histopathology and antioxidant status were examined.
Results: MT impaired GTT, caused alteration in histopathology of histopathology and antioxidant status of liver in non-diabetic rats. Impairment in GTT did not observe in diabetic rats exposed to MT, but histopathology changes and antioxidant status alteration was more severe.
Conclusion: Repeated sub-lethal dose of MT exacerbated hepatotoxicity in diabetes condition through further impairment in the antioxidant defense system.
کلمات کلیدی: Organophosphorus, Diabetes, Liver, Oxidative stress
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1872439/